Isoform-Specific Inhibition of Cyclophilins
نویسندگان
چکیده
منابع مشابه
Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties.
Dihydropyridines (DHPs) block L-type Ca2+ channels more potently at depolarized membrane potentials, consistent with high affinity binding to the inactivated state. Nisoldipine (a DHP antagonist) blocks the smooth muscle channel more potently than the cardiac one, a phenomenon observed not only in native channels but also in expressed channels. We examined whether this tissue specificity was at...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi9007287